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肿瘤促进剂本身并不具有致癌性.但能促使预先用亚适量的某种化学致癌剂处理过的动物发生肿瘤.最近阐明,多种类型的哺乳动物细胞具有与法波酯亲合力很高的受体.有人认为,在正常情况下这些受体与某些内源拮抗剂或配体结合,如果这些物质存在,它们可能产生与法波酯相似的生物化学和生物学效应,并能起着内源肿瘤促进剂或致癌作用调节剂的作用.应注意的是12-○-四癸酰-法波-13-乙酸酯(12-O-tetradeca-
Tumor promoters are not carcinogenic in nature, but can promote tumors in animals that have previously been treated with a suboptimal amount of a certain chemical carcinogen. Recently it has been demonstrated that many types of mammalian cells have a high affinity for farnesyl esters. Receptors. Some people think that under normal circumstances these receptors bind to certain endogenous antagonists or ligands. If these substances are present, they may produce similar biochemical and biological effects as farnesyl esters and can Role of Endogenous Tumor Accelerators or Carcinogenesis Modifiers. It should be noted that 12-O-tetradecanoyl-farneso-13-acetate (12-O-tetradeca-