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目的:观察纳洛酮治疗烧伤休克合并脑水肿的临床疗效。方法:选择烧伤休克合并脑水肿52例,随机分为观察组和对照组各26例。对照组入院后进行简单清创、抗感染、抗休克及应用地塞米松和甘露醇等常规治疗;观察组在常规治疗基础上连续静脉滴注纳洛酮7天。比较两组临床疗效。结果:两组治疗后临床各项指标均较治疗前有不同程度改善,观察组改善程度显著优于对照组(P<0.05)。结论:在常规治疗基础上加用纳洛酮救治烧伤合并脑水肿疗效较好。
Objective: To observe the clinical efficacy of naloxone in treatment of burn shock and cerebral edema. Methods: Fifty-two burn shock patients with cerebral edema were randomly divided into observation group and control group with 26 cases in each group. The patients in the control group were treated with simple debridement, anti-infection, anti-shock and dexamethasone and mannitol. The patients in the observation group were given naloxone intravenously for 7 days on the basis of routine treatment. The clinical efficacy of the two groups were compared. Results: After treatment, the clinical indexes in both groups improved to some extent before treatment, and the improvement in the observation group was significantly better than that in the control group (P <0.05). Conclusion: The addition of naloxone on the basis of conventional treatment is effective in treating burns complicated with cerebral edema.