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镁盐(硫酸镁或氯化镁)不仅对低镁血症引起的心律失常有效,而且对血镁浓度正常的室性心动过速和毛地黄中毒引起的心律失常也有效,但镁对心肌的作用和抗心律失常作用的机制尚未明确。我们对正常犬和冠状动脉结扎犬,测定硫酸镁静脉注射前后的室性过早搏动阈值及心室颤动阈值(VFT),研究了镁对心室兴奋性及心室颤动阈值的影响。
Magnesium salts (magnesium sulfate or magnesium chloride) are not only effective for arrhythmias caused by hypomagnesemia but are also effective against arrhythmias caused by normal serum magnesium concentrations in ventricular tachycardias and digitoxin-induced poisoning, but the effects of magnesium on myocardium and The mechanism of antiarrhythmic effect is not yet clear. We ligated dogs to normal dogs and coronary arteries to determine ventricular premature beats and ventricular fibrillation thresholds (VFT) before and after intravenous injection of magnesium sulfate. The effects of magnesium on ventricular excitability and ventricular fibrillation threshold were investigated.