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目的通过比较老年患者与非老年患者在输血治疗过程中出现的输血相关不良反应的状况,分析老年患者输血治疗出现不良反应的特征,以达到促进老年患者临床安全用血的目的。方法选取2011年1月至2016年1月某三甲医院8 787例住院患者输血病例进行回顾性分析,比较老年患者组与非老年患者组各类型输血相关不良反应的差异。结果老年患者组接受输血治疗后,输血相关不良反应的发生率为2.33%,高于非老年患者组的发生率(1.29%),差异有统计学意义(P<0.05)。其中老年患者组循环超负荷的发生率为19.40%,输血相关性铁过载的发生率为22.39%,均高于非老年患者组的发生率(5.13%、7.69%),差异有统计学意义(P<0.05);其他类型输血相关不良反应的发生率与非老年患者组间差异无统计学意义(P>0.05)。结论老年患者由于病史复杂、机体各器官功能自然衰退、临床输血需求以及部分输血相关不良反应发生率较非老年患者高,在进行输血治疗时应得到临床工作者的谨慎关注。
Objective To compare the characteristics of transfusion-related adverse reactions during the transfusion therapy in elderly patients and non-elderly patients and to analyze the characteristics of adverse reactions in transfusion therapy in elderly patients so as to achieve the goal of promoting clinical blood safety in elderly patients. Methods A retrospective analysis of 8 787 inpatients with transfusion from January 2011 to January 2016 in a hospital was conducted to compare the differences of transfusion-related adverse reactions between the elderly and non-elderly patients. Results The incidence of transfusion-related adverse reactions was 2.33% in the elderly patients receiving transfusion therapy, which was significantly higher than that in non-elderly patients (1.29%) (P <0.05). Among them, the incidence of circulatory overload in elderly patients was 19.40%, and the incidence of transfusion-related iron overload was 22.39%, which were higher than those in non-elderly patients (5.13%, 7.69%), the difference was statistically significant P <0.05). There was no significant difference in the incidence of other types of transfusion-related adverse reactions between non-elderly patients (P> 0.05). Conclusion Due to the complicated history, the natural decline of organ function in the elderly patients, the need of clinical transfusion and the incidence of some transfusion-related adverse reactions are higher than those in non-elderly patients. Careful attention should be paid by clinicians during transfusion therapy.