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国家心肺血液研究院对急性心肌梗塞(AMI)后的心律失常进行了前瞻性研究(The Cardiac Arr-hythmia Pilot Study:CAPS)。对于应用药物抑制AMI后室性心律失常的可行性进行了评价。CAPS按随机、双盲、安慰剂对照的方法进行。由10所医学研究中心参加。从近4000例AMI患者中,选出502例受试者。他们都符合下列条件:AMI后6～60天;年龄<75岁;24小时动态心电图记录上室性早搏(VPC)平均频度≥10次/小时,或者短阵室(性心动过)速(连续VPC 3～9次,速率≥100/分)≥5阵/24小时;左室射血分数(LVEF)>20％。随机分组后一年内,死亡7例(1.4％),均与试验药物无关;
The National Heart, Lung and Blood Institute conducted a prospective study of arrhythmias following acute myocardial infarction (AMI) (The Cardiac Arr-hythmia Pilot Study: CAPS). The feasibility of using drugs to inhibit ventricular arrhythmia after AMI was evaluated. CAPS were conducted in a randomized, double-blind, placebo-controlled manner. By the 10 medical research center to participate. Of nearly 4000 AMI patients, 502 subjects were selected. They all met the following criteria: 6 to 60 days after AMI; age <75 years; 24 hours VG recording average VPC ≥10 beats / hour or bradycardia (tachycardia) Continuous VPC 3 ~ 9 times, the rate of ≥ 100 / min) ≥ 5/24 hours; left ventricular ejection fraction (LVEF)> 20%. Seven patients (1.4%) died within one year after randomization, all of which had nothing to do with the test drug.