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目的探讨沙苑子黄酮(FAC)对CCl4致小鼠慢性肝纤维化的保护作用。方法制备小鼠慢性肝纤维化模型,给予FAC灌服,并以秋水仙碱为对照,检测血清ALT、AST、ALB及肝组织Hyp、MDA、SOD水平的变化。同时观察肝组织的病理变化和肝组织中过氧化物酶体增殖物激活受体γ蛋白的表达情况。结果与正常对照组相比,模型组小鼠血清ALT、AST水平显著升高,ALB水平显著降低(P<0.01)。与模型组相比,FAC各剂量组小鼠血清ALT、AST显著降低,ALB水平显著升高(均P<0.01)。FAC各剂量组可显著升高肝组织中SOD活性及PPARγ的表达,降低MDA、Hyp的含量(P<0.01或P<0.05)。结论FAC有显著改善肝功能、预防肝纤维化作用,其机制可能与其抗脂质过氧化和提高机体的抗氧化酶活性有关。
Objective To investigate the protective effect of FAC on chronic hepatic fibrosis induced by CCl4 in mice. Methods Chronic liver fibrosis model was induced in mice. FAC was administered orally and the changes of ALT, AST, ALB, hepatic Hyp, MDA and SOD were detected with colchicine as control. At the same time, the pathological changes of liver tissue and the expression of peroxisome proliferator activated receptorγprotein in liver tissue were observed. Results Compared with the normal control group, the levels of serum ALT and AST in the model group were significantly increased and the levels of ALB were significantly decreased (P <0.01). Compared with model group, serum ALT, AST and ALB levels in FAC groups were significantly increased (all P <0.01). The FAC dose groups could significantly increase the activity of SOD and the expression of PPARγ in liver tissue and decrease the content of MDA and Hyp (P <0.01 or P <0.05). Conclusion FAC can significantly improve liver function and prevent hepatic fibrosis. The mechanism may be related to its anti-lipid peroxidation and anti-oxidative enzyme activity.