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近10年来寄生虫病的化疗进展较快,而利什曼病和非洲锥虫病的化疗至今毫无进展。丝虫病的化疗进展也不大,自1947年开始应用的海群生至今仍是主要的抗丝虫药。近二年来,虽然在试用伊维菌素(Ivermectine)治疗盘尾丝虫病,但尚未看到它的疗效。对麦地那龙线虫病的治疗,尚无有效药物。然而,近10年来发现了不少疗效高、耐受性好、疗程短、服用方便的抗虫新药。一、治疗肠道原虫病的硝基咪唑类药物(表1)。(一)药理学:第2代5-硝基咪唑类包
Chemotherapy for parasitic diseases has progressed rapidly in the last 10 years, but chemotherapy for leishmaniasis and African trypanosomiasis has so far made no progress. Progress in the treatment of filariasis is not great, and the sea fauna that has been in use since 1947 is still the major anti-filarial drug. In the past two years, although Ivermectine is being tested for onchocerciasis, its efficacy has not been seen. There is no effective medicine for the treatment of dracunculiasis. However, in the past 10 years, many new anti-insect drugs have been found with high efficacy, good tolerance, short course of treatment and convenient administration. First, the treatment of intestinal parasitic disease nitroimidazole drugs (Table 1). (A) Pharmacology: The second generation of 5-nitroimidazole package