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我们曾发现在不明显损伤培养的猪主动脉内皮细胞的情况下,内毒素以剂量和时间依赖的方式显著刺激其前列环素(PGI_2)的生成。Suttorp 等报道内毒素对猪肺动脉内皮细胞 PGI_2生成的刺激作用至少有赖于1%血清的存在。由于不同种类和不同血管的内皮细胞对内毒素的敏感性不同,我们对
We have found that endotoxin significantly stimulates the production of prostacyclin (PGI_2) in a dose- and time-dependent manner without significantly damaging cultured porcine aortic endothelial cells. Suttorp et al reported that endotoxin stimulation of PGI 2 production in porcine pulmonary artery endothelial cells depends at least on the presence of 1% serum. Due to the different endotoxin sensitivity of endothelial cells of different species and different blood vessels,