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Obesity is a major health problem across the world,but there are few ways to effectively treat or manage it in the long term.Researchers are searching for more convenient,cost-effective and noninvasive therapies for overweight and obese people.Recent studies have illustrated that the microbiome of the body’s different organs can be used as a vehicle for in-situ gene therapy.We suggest that the recombinant form of “Pichia pastoris” yeast expressing the hybrid protein of “irisin-furin-transferrin” under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients,and induce a higher metabolic rate to expend more calories,similar to that from engaging in physical activity.By comparison,this method can be a long-term,noninvasive treatment and can be used for obese patients who have movement limitations.
Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. the microbiome of the body’s different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of “Pichia pastoris” yeast expressing the hybrid protein of “irisin-furin-transferrin ” under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity.By comparison, this method can be a long-term , noninvasive treatment and can be used for obese patients who have movement limitations.