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1.在麻醉大白鼠腔道灌流标本上,研究了甲氰咪胺对基础胃酸分泌的影响。2.6只预先口服大剂量甲氰味胺的大白鼠基础胃酸分泌与6只对照大白鼠相比较无显著差异.3.静注甲氰味胺1毫克、8毫克不能明显抑制基础胃酸分泌。4.静注甲氰咪胺后,在基础胃酸分泌超过2.5微克当量/10分的大白鼠虽显示基础胃酸分泌一致有所减少,但在基础胃酸分泌低于此值的大白鼠则未见这种影响。5.这些结果正与甲氰咪胺显著抑制人的基础胃酸分泌相反,并讨论了可能的原因.
1. In the anesthetized rat cavity perfusion specimens, the study of cimetidine basic gastric acid secretion. There was no significant difference between the basal gastric acid secretion of 2.6 pre-oral administration of high-dose methylamine in rats and the 6 control rats.3.An intravenous methyl-cyanamide 1 mg, 8 mg did not significantly inhibit basal gastric acid secretion. 4. After intravenous cidamerazine, basal gastric acid secretion in basal gastric acid secretion more than 2.5 microgram equivalents / 10 points, although the basic gastric acid secretion decreased, but in the basal gastric acid secretion below this value is not seen in this rat Influence. 5. These results are in contrast to mecamylamine significantly inhibiting basal gastric acid secretion in humans and discuss possible causes.