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目的研究宽叶缬草(Valeriana officinalis Linn.var.latiofolia Miq.)根的水溶性化学成分。方法利用大孔树脂Diaion HP-20柱色谱、硅胶柱色谱、Sephadex LH-20柱色谱等手段对宽叶缬草根的水溶性成分进行分离纯化,应用质谱、1D核磁共振光谱(NMR)、2DNMR等方法对分得的化合物进行结构鉴定。结果和结论从宽叶缬草根中分离并鉴定了13个化合物,分别为甘西鼠尾甲苷A(1)、当归棱子芹醇葡萄糖苷(2)、(-)-当归棱子芹醇-2-O-β-D-呋喃芹菜糖基-(1→6)-β-D-吡喃葡萄糖苷(3)、6-羟基-7-羟甲基-4-亚甲基六氢环戊骈吡喃-1(3H)-酮(4)、缬草苷A(5)、双四氢呋喃木脂素-4-O-β-D-吡喃葡萄糖苷(6)、(+)-松脂酚-4-O-β-D-吡喃葡萄糖苷(7)、小蜡苷Ⅰ(8)、青木香苷A(9)、(+)-1-羟基松脂酚-1-O-β-D-葡萄糖苷(10)、(+)-松脂酚-4,4′-O-二吡喃葡萄糖苷(11)、(+)-环橄榄脂素-6-O-β-D-吡喃葡萄糖苷(12)、松柏苷(13)。所有化合物均为首次从该植物中分离得到。
Aim To study the water-soluble chemical constituents of the root of Valeriana officinalis Linn.var.latiofolia Miq. Methods The water-soluble constituents of Valeriana officinalis were isolated and purified by using macroporous resin Diaion HP-20 column, silica gel column and Sephadex LH-20 column chromatography. Mass spectra, 1D nuclear magnetic resonance (NMR) and 2D NMR Methods The compounds were identified by structure. RESULTS AND CONCLUSION Thirteen compounds were isolated and identified from the roots of Valeriana officinalis. They were Glycyrrhizin A (1), Angelica Crenulatum Glucoside (2), (-) - Angelica Rhynchophylla -2-O-β-D-furanosylglycosyl- (1 → 6) -β-D-glucopyranoside (3), 6- hydroxy-7-hydroxymethyl- (4), Valerianoside A (5), Bistetrahydrofo lignol-4-O-β-D-glucopyranoside (6), (+) - Turpentine Phenol-4-O-β-D-glucopyranoside (7), Myricetin Ⅰ (8), Aconitin A (9) D-glucoside (10), (+) - terpineol-4,4’-O-diglucopyranoside (11), Glucoside (12), coniferin (13). All compounds were isolated from this plant for the first time.