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腹部创伤患者早期即可出现凝血功能的变化。为探讨腹部创伤患者凝血功能的紊乱情况。本文将51例病人依据APACHE Ⅱ评分分为对照组和危重组,测定抗凝血酶Ⅲ(AT—Ⅲ),血小板颗粒膜蛋白(GMP—140),血管性假血友病因子(VWF),纤维蛋白原(Fg),组织纤溶酶原激活物(t—PA),纤溶酶原(Plg),纤溶酶原激活物抑制剂(PAI),交联纤维蛋白降解产物(D—D)。结果AT—Ⅲ活性下降,VWF.GMP—140值升高,t—PA、Plg活性下降,D—D值升高,PAI活性升高,且危重组变化更为显著。结果表明,严重创伤患者凝血功能变化复杂,既有凝血和纤溶系统的激活,也有血小板和血管内皮细胞受损,同时伴有纤溶受抑,在临床治疗中应注意其血液高凝状态的变化。
Abdominal trauma patients can appear early coagulation changes. To investigate the coagulation disorders in patients with abdominal trauma. Fifty-one patients were divided into control group and critically ill group according to APACHE II score, and the levels of AT-III, GMP-140, VWF, Fibrinogen, t-PA, Plg, PAI, D-D ). Results AT-Ⅲ activity decreased, VWF-GMP-140 value increased, t-PA, Plg activity decreased, D-D value increased, PAI activity increased, and the changes in the more severe group more significant. The results showed that patients with severe trauma complicated changes in blood coagulation, both coagulation and fibrinolytic system activation, but also platelet and endothelial cell damage, accompanied by fibrinolytic suppression, in clinical treatment should pay attention to the blood hypercoagulable state Variety.