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盐酸戊脉安常与一定量的其它静脉注射药物混合使用。根据盐酸戊脉安(下简称VP)与盐酸杜丁胺(Dobutarmine 下简称DB)在0.9%氯化钠和5%葡萄糖注射液中配伍,于24h 后出现淡粉色,本文对此配伍液的化学稳定性作了进一步的探讨。实验用HPLC 色谱仪(AL202型)进行测定。样品液贮于塑料袋和棕色瓶中于24°和5°贮存7天。在贮存前、贮存中的不同间隔期,取样一式三份进行HPLC测定。记录pH 和外观变化。DB 流动相为含20%乙氰
Vaporamil hydrochloride is usually mixed with a certain amount of other IV drugs. According to the compatibility of verapamil hydrochloride (hereinafter referred to as VP) and dobutamine hydrochloride (DB) in 0.9% sodium chloride and 5% glucose injection, pale pink appeared after 24 hours. In this paper, Stability has been further explored. The experimental HPLC chromatograph (Model AL202) was used for the determination. Samples were stored in plastic bags and brown bottles for storage at 24 ° and 5 ° for 7 days. Samples were taken in triplicate for HPLC determination prior to storage and at different intervals during storage. Record pH and appearance changes. DB mobile phase containing 20% acetonitrile