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目的分析陕西省户县乙型肝炎感染现状,为更好地制定不同防制策略提供依据。方法采用酶联免疫吸附实验方法(ELISA)检测血清中乙型肝炎感染标志,结果判定参照GB 17010-1997,数据处理采用常用统计方法和文献系统综述方法。结果 2005—2009年该县累计检测血清中乙型肝炎感染标志46142人,各类人群HBsAg阳性率平均为5.46%(2 521/46 142),数值波动在1.25%～5.57%之间,明显低于全国水平(u=30.4078,P<0.01)。抗-HBs累计检测2 092人,抗-HBs阳性率为37.67%(各类人群波动在2.85%～47.63%之间),不同人群间阳性率差异有统计学意义(χ2=461.42,P<0.01)。抗-HBs阳性率最高为体检人员(47.63%),其次为医务人员(41.88%)和公务员(40.7%),3类人员平均阳性率为42.31%,经χ2检验,差异有统计学意义(χ2=323.214 4,P<0.01)。结论该县乙型肝炎感染现状分析、研究,对了解感染指标变化、控制乙肝传播有重要意义。
Objective To analyze the current status of hepatitis B infection in Huxian County of Shaanxi Province and provide evidence for better formulating different prevention and control strategies. Methods Serum samples of hepatitis B were detected by enzyme-linked immunosorbent assay (ELISA). The results were determined according to GB 17010-1997. The data processing methods were general statistical methods and literature review methods. Results In 2005-2009, 46,142 hepatitis B infection markers were detected in this county. The average positive rate of HBsAg in all kinds of people was 5.46% (2 521/46 142), and the value fluctuated between 1.25% -5.57% At the national level (u = 30.4078, P <0.01). The detection rate of anti-HBs was 2 092, the positive rate of anti-HBs was 37.67% (the fluctuation of all kinds of people was between 2.85% -47.63%), the positive rate of different groups was statistically different (χ2 = 461.42, P <0.01 ). The highest positive rates of anti-HBs were physical examination (47.63%), followed by medical staff (41.88%) and civil servants (40.7%), and the average positive rate of the three kinds of workers was 42.31% (χ2 test, the difference was statistically significant = 323.214 4, P <0.01). Conclusion The status analysis and study of hepatitis B in this county is of great significance in understanding the change of infection index and controlling the spread of hepatitis B.