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目的 研究单纯性肥胖病人空腹和餐后血浆β内啡肽（β Ｅｐ） 水平变化。方法 ２０ 例肥胖症患者和１２ 例正常对照组在隔夜空腹后，于试餐前及餐后３０ 分钟、６０ 分钟、１２０ 分钟和１８０ 分钟采血６ ｍｌ，用放射免疫法测定血浆β Ｅｐ 、胰岛素、皮质醇和 Ａ Ｃ Ｔ Ｈ 水平。结果 肥胖组基础血浆β Ｅｐ 和胰岛素水平明显高于对照组（ Ｐ＜ ０ ．００１ 和０ ．０１） ，肥胖组基础血浆β Ｅｐ 与 Ｂ Ｍ Ｉ无相关性（ ｒ ＝ ０ ．１０３ ， Ｐ＞ ０ ．２０） ，肥胖组β Ｅｐ 曲线下面积与 Ａ Ｃ Ｔ Ｈ 曲线下面积无相关性（ ｒ ＝ ０ ．１３２ ， Ｐ＞ ０ ．０５） 。结论 高β Ｅｐ 血症可能是与肥胖特征有关的一种现象，可将β Ｅｐ 做为肥胖症诊断的实验室参考指标之一，但不能将β Ｅｐ 作为反映肥胖症程度的指标。
Objective To study the changes of fasting and postprandial plasma beta-endorphin (β-Ep) levels in simple obesity patients. Methods Twenty patients with obesity and 12 normal controls were given 6ml blood samples before and after meals, 30 minutes, 60 minutes, 120 minutes and 180 minutes after the fasting meal. Plasma β-Ep, insulin , Cortisol and A C T H levels. Results The plasma levels of β Ep and insulin in the obese group were significantly higher than those in the control group (P 0.001 and 0. 01). There was no correlation between β Ep in the obese group and B M I in the obese group (r = 0.103, P > 0.20). The area under the curve of β-Ep in obesity group was not related to the area under the curve of A C T H (r = 0.132, P> 0.05). Conclusions High β-Epidemia may be a phenomenon related to obesity characteristics. Β-Ep may be used as a laboratory reference index for the diagnosis of obesity. However, β-Ep should not be used as an indicator of the degree of obesity.