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目的观察外源性促性腺激素治疗低促性腺激素性闭经致不孕不育患者的临床效果。方法收集2014年1月-2015年1月该院收治的低促性腺激素性闭经致不孕不育患者68例,采用外源性的促性腺激素(戊酸雌二醇片、醋酸甲羟孕酮片)进行治疗,对医治前后患者相关激素的水平进行检测比较,包括黄体生成素(LH)、卵泡刺激素(FSH)、孕酮(P)、雌二醇(E2)和催乳素(PRL),同时对医治前后子宫的变化进行对比,计算评估患者妊娠成功的概率。结果与治疗前相比,治疗后患者的LH、FSH、P、E2及PRL水平均显著升高(P<0.05)。治疗后患者子宫体积、卵巢休积及子宫内膜厚度大于治疗前,优势卵泡个数多于治疗前,差异均有统计学意义(P<0.05)。68例患者进行药物治疗后,有52例患者成功妊娠,成功率高达76.5%。结论外源性的促性腺激素对低促性腺激素性闭经致不孕不育患者的治疗效果明显,有助于帮助提高患者的妊娠几率,值得临床推广。
Objective To observe the clinical effect of exogenous gonadotropin on infertility patients with hypo-gonadotropin amenorrhea. Methods Sixty-eight patients with hypogonadotrophic amenorrhea infertility who were admitted to our hospital from January 2014 to January 2015 were enrolled in this study. Exogenous gonadotropin (estradiol valerate, medroxyprogesterone acetate) Ketone tablets), the levels of related hormones in patients before and after treatment were detected and compared, including LH, FSH, PR, PRL ), While changes in the uterus before and after treatment were compared, calculated to assess the probability of pregnancy success. Results Compared with before treatment, the levels of LH, FSH, P, E2 and PRL in patients after treatment were significantly increased (P <0.05). After treatment, the uterus volume, ovarian volume and endometrial thickness were greater than those before treatment, and the number of dominant follicles was more than that before treatment (P <0.05). In 68 patients after drug treatment, 52 patients with successful pregnancy, the success rate as high as 76.5%. Conclusions Exogenous gonadotropin has a significant therapeutic effect on patients with infertility caused by hypogonadotrophic amenorrhea, which may help to improve the probability of pregnancy in patients. It is worthy of clinical promotion.