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探讨中药治疗痤疮机理 ,验证痤疮颗粒的主要药理作用。选择昆明种小鼠和Wistar大鼠 ,进行体内抗菌、抗炎、对耳廓微循环的影响实验。结果 ,痤疮颗粒对腹腔感染金黄色葡萄球菌的小鼠有明显的体内保护作用 ,存活率为 70 % ;对醋酸所致小鼠腹腔毛细血管通透性亢进有一定抑制作用 ;对CMC引起的炎症渗出液中白细胞数量抑制率为 6 2 6 5 % ;扩张小鼠耳廓细动脉和细静脉 ,与空白对照组比较P <0 0 1,P <0 0 5。痤疮颗粒具有体内抗菌、抗炎及改善微循环作用。验证了本品清热除湿、凉血活血、解毒消肿功能。
Explore the mechanism of Chinese medicine treatment of acne, verify the main pharmacological effects of acne granules. Kunming mice and Wistar rats were selected for in vivo antibacterial, anti-inflammatory, and auricular microcirculation effects. As a result, acne granules had significant protective effect on mice infected with Staphylococcus aureus in the abdominal cavity, and the survival rate was 70%; it had a certain inhibitory effect on acetic acid-induced abdominal capillary hyperpermeability; and it caused inflammation in CMC. The inhibitory rate of white blood cells in exudate was 6 2 6 5 %. The auricular arterioles and venules in mice were expanded. Compared with the control group, P <0 0 1, P <0 05. Acne particles have antibacterial, anti-inflammatory and microcirculatory effects in vivo. The product was verified to have heat, dehumidification, cooling and blood circulation, detoxification and swelling.