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自1962年应用先锋霉素Ⅰ以来,鲜见其所致粒细胞减少的报道。本文报告一年内该药所致4例粒细胞减少。诊断标准为粒细胞少于1000/立方毫米,无引起中性白细胞减少的其它原因,如恶性病、胶原病、脾机能亢进、放射线治疗或化学治疗。表为先锋霉素Ⅰ所致4例粒细胞减少的摘要。本品静脉注射,每日4～12克。患者均未发生由粒细胞减少引起的溃疡性咽炎或急性疾患。红细胞或血小板数无明显减少。2例骨髓检查表明其特征为髓细胞或晚髓细胞成熟受抑制。停药后外周血象的粒细胞迅速增高而整个血象在5天内恢复正常。所用的其它药物有普鲁卡因酰胺、阿斯匹林、扑热息痛、安定、氟氨安定、速可眠
Since the application of Pioneermycin Ⅰ in 1962, rare cases of neutropenia have been reported. This article reports 4 cases of neutropenia caused by this medicine in a year. Diagnostic criteria for granulocytes less than 1000 / cubic millimeter, neutropenia caused no other causes, such as malignant, collagen disease, hypersplenism, radiation therapy or chemotherapy. Table for the cephalosporin Ⅰ caused by 4 cases of neutropenia summary. This product intravenously, 4 to 12 grams daily. None of the patients developed ulcerative pharyngitis or acute conditions caused by neutropenia. No significant reduction in the number of red blood cells or platelets. 2 cases of bone marrow examination showed that the characteristics of myeloblasts or mature cells were inhibited. After stopping the peripheral blood like granulocytes rapidly increased and the entire blood returned to normal within 5 days. Other drugs used are procainamide, aspirin, paracetamol, diazepam, flurbamycin, asleep