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目的观察腹腔热灌注顺铂联合卡培他滨治疗胃癌腹腔积液的临床效果。方法 MTT法检测42℃时顺铂对胃癌细胞的生长抑制功效,选取本院2010年3月至2011年5月50例晚期胃癌腹腔积液患者,通过腹腔热灌注顺铂联合卡培他滨治疗观察临床治疗效果和不良反应。结果 42℃热疗能够极大加强顺铂对胃癌细胞的生长抑制作用,热灌注顺铂联合卡培他滨治疗胃癌腹腔积液的有效率为70%(35/50),不良反应较少。结论热疗可以极大提高胃癌细胞顺铂的毒性作用,热灌注顺铂联合卡培他滨对于晚期胃癌腹腔积液的治疗效果显著。
Objective To observe the clinical effect of intraperitoneal hot perfusion of cisplatin combined with capecitabine in the treatment of gastric cancer with ascites. Methods The inhibitory effect of cisplatin on the growth of gastric cancer cells at 42 ℃ was determined by MTT assay. Fifty patients with advanced gastric cancer with ascites from March 2010 to May 2011 were selected and treated with intraperitoneal hot cisplatin plus capecitabine To observe the clinical treatment and adverse reactions. Results 42 ℃ hyperthermia can greatly enhance the inhibitory effect of cisplatin on the growth of gastric cancer cells. The effective rate of hot perfusion of cisplatin combined with capecitabine in the treatment of gastric cancer with ascites was 70% (35/50) with less adverse reactions. Conclusion Hyperthermia can significantly increase the toxicity of cisplatin in gastric cancer cells. The combination of Cisplatin and capecitabine is effective in the treatment of advanced gastric cancer with ascites.