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目的 探讨类风湿性关节炎 (RA)患者血清淀粉样蛋白 A(SAA)、白细胞介素 - 1β(IL- 1β)、白细胞介素 - 6 (IL- 6 )及 C反应蛋白 (CRP)水平检测的临床意义。方法 采用酶联免疫吸附实验检测 5 1例 RA患者及 41例正常对照组血清中 IL-1β、IL- 6、SAA和 CRP水平。结果 RA患者 IL- 1β、IL- 6、SAA和 CRP水平明显高于正常对照组 (P<0 .0 1) ,RA活动组与 RA稳定组 IL- 1β、IL- 6及 SAA水平有极显著差异 (P<0 .0 1) ,CRP则无明显变化。结论 IL- 1β、IL- 6及 SAA在判断 RA的活动性方面具有较高的敏感性 ,对监测 RA的疗效有一定作用
Objective To investigate the levels of serum amyloid A (SAA), interleukin - 1β (IL - 1β), interleukin - 6 (IL - 6) and C - reactive protein (CRP) in patients with rheumatoid arthritis The clinical significance. Methods Serum levels of IL-1β, IL-6, SAA and CRP in 51 RA patients and 41 normal controls were detected by enzyme-linked immunosorbent assay. Results The levels of IL-1β, IL-6, SAA and CRP in RA patients were significantly higher than those in normal controls (P <0.01). The levels of IL-1β, IL-6 and SAA in RA patients and RA patients were significantly higher Difference (P <0 01), CRP no significant change. Conclusion IL-1β, IL-6 and SAA are highly sensitive in judging the activity of RA and have a certain effect on monitoring the curative effect of RA