荧光光度法测定 MDA及阿霉素在小鼠肝细胞内的含量 ;研究茶多酚抑制 MDA的生成与阿霉素胞内蓄积的关系。结果表明 ,茶多酚浓度为 1 0 ,2 0 ,40 ,80 ,1 60 mg/L时对 MDA生成的抑制率分别为 44.87% ,1 1 5.1 7% ,1 77.2 5% ,1 81 .98% ,1 82 .37% ,且与剂量成正相关。在·OH诱导下 ,茶多酚浓度为 40 mg/L时 ,可明显增加阿霉素在小鼠肝组织细胞内的蓄积 The content of MDA and doxorubicin in mouse liver cells was measured by fluorescence spectrophotometry. The relationship between the inhibition of MDA production by tea polyphenols and intracellular accumulation of adriamycin was studied. The results showed that the inhibitory rates of MDA production at tea polyphenols concentrations of 10, 20, 40, 80, and 160 mg/L were 44.87%, 11 1 7%, 177.25%, 1 81 .98, respectively. %, 1 82.37%, and positively correlated with dose. Under the induction of OH, tea polyphenols concentration of 40 mg/L significantly increased the accumulation of doxorubicin in mouse liver cells.