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目的探讨单纯碘过量对雌性大鼠血清甲状腺激素(T3、T4、FT3、FT4和TSH)水平的影响。方法选择成年雌性大鼠40只,随机分为4个组(每组10只):适碘组(NI)、高碘3个组(饮用水加入不同剂量的碘化钾(KI)),大鼠饲养3个月处死后取血离心检测血清甲状腺激素浓度水平。检测结果 EPI6.0双录入,分析用SPSS19.5统计软件。结果高碘组雌性大鼠血清T3、FT3、T4和FT4浓度与适碘组比较有所降低,但差异无统计学意义(P>0.05),随着KIO3浓度的升高,各组血清T3、FT3、T4和FT4水平也随之降低;高碘组雌性大鼠血清TSH浓度与适碘组比较有所升高,差异有统计学意义(P<0.05)。结论单纯的碘过量是甲状腺疾病的可能致病因素之一,所以因地制宜根据碘缺乏病的监测结果,及时调整盐碘浓度对于防治甲状腺疾病的发生具有重要意义。
Objective To investigate the effects of excessive iodine alone on serum thyroid hormones (T3, T4, FT3, FT4 and TSH) in female rats. Methods Forty adult female rats were randomly divided into four groups (n = 10): NI group, high iodine group (KI group) with different doses of potassium iodide (KI) Serum thyroid hormone levels were measured by centrifugation at 3 months after sacrifice. EPI6.0 test results double entry, analysis using SPSS19.5 statistical software. Results Serum concentrations of T3, FT3, T4 and FT4 in the rats of the high iodine group were lower than those in the healthy controls (P> 0.05), but no significant difference was found between the two groups (P> 0.05). With the increase of KIO3 concentration, The level of FT3, T4 and FT4 also decreased. The serum TSH level in the high iodine group was higher than that in the iodine group, the difference was statistically significant (P <0.05). Conclusions Simple iodine excess is one of the possible causes of thyroid disease. Therefore, adjusting the salt-iodine concentration in time according to the monitoring results of iodine deficiency disorders is of great significance for the prevention and treatment of thyroid diseases.