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2-甲基间二酚或5-甲基间二酚分别与dl-苹果酸或乙酰乙酸乙酯,在浓硫酸催化下,经Peachmann缩合反应得到伞型酮(7-羟基香豆素)类似物5～7.5～7经甲基化得新化合物5a,6a和7a;经Williamson反应,TBAB(四正丁基溴化铵)相转移催化合成了14个新的香豆素类化合物5b～5e,6b～6f,7b～7f.经IR,MS,1HNMR及元素分析对所有化合物的结构进行了表征.初步生物活性实验结果表明,在50μg/mL浓度下,化合物6对辣椒疫霉病菌(Phytophythora capsici)抑制率达58.5%,化合物7c对番茄灰霉病菌(Botrytis cinerea)抑制率为54.0%,化合物6c对水稻纹枯病菌(Rhizoctonia solani)的抑制率达83.7%.
2-methyl-2-methyl-2-phenol or 5-methyl-2-methyl-phenol and dl-malic acid or ethyl acetoacetate respectively. Peachmann condensation reaction catalyzed by concentrated sulfuric acid New compounds 5a, 6a and 7a were obtained by methylation of compounds 5 ~ 7.5 ~ 7. 14 new coumarins 5b ~ 5e were synthesized by Williamson reaction and TBAB (tetra-n-butylammonium bromide) , 6b ~ 6f, 7b ~ 7f.The structures of all the compounds were characterized by IR, MS, 1HNMR and elemental analysis.The results of preliminary bioassay showed that at the concentration of 50μg / mL, the effect of compound 6 on Phytophythora The inhibitory rate of compound 7c to Botrytis cinerea was 58.5% and that of compound 6c to Rhizoctonia solani was 83.7%.