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手足口病(HFMD)是夏秋季婴幼儿和儿童的主要急性传染病之一,该病以口腔黏膜疹、皮肤溃疡和手、足部的疱疹为主要特征,具有播散快、流行性强的特点,并可在短时间内造成规模流行。自1958年Robinson报道首例HFMD以来,柯萨奇病毒A组16型(CoxA16)和肠道病毒71型(EV71)先后成为HFMD流行的主要病原,两种病毒基因型相似并且表现类似的临床症状。其中EV71可引起严重中枢神经系统并发症,如脑膜炎、脑炎、
Hand, foot and mouth disease (HFMD) is one of the major acute infectious diseases in infants and children in summer and autumn. The disease is mainly characterized by oral mucosal rash, skin ulcers and hand and foot herpes. It has the characteristics of rapid spread and epidemic Features, and can cause scale in a short time popular. Since the first HFMD was reported by Robinson in 1958, Coxsackie A, type 16 (CoxA16) and enterovirus 71 (EV71) have been the major pathogens of HFMD epidemics in succession, with similar genotypes and similar clinical signs . Which EV71 can cause serious central nervous system complications such as meningitis, encephalitis,