应用反相蒸发法制备出重组人铜锌超氧化物歧化酶(rh Cu/Zn SOD)脂质体,其包封率为49.1%,在大鼠体内半衰期为3.45 h,体外模拟胃酸、胃蛋白酶、胰酶耐受力分别为90.3%、86.2%.79.8%;在小鼠体内脾、肝、肺脏中分布最高. The rh Cu / Zn SOD liposome was prepared by reverse phase evaporation. The entrapment efficiency was 49.1%. The half-life in vivo was 3.45 h. The in vitro model of gastric acid, pepsin , And the trypsin tolerance was 90.3%, 86.2% and79.8%, respectively. The highest distribution was found in the spleen, liver and lung of mice.