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目的 了解血浆可溶性血栓调节蛋白（ｓＴＭ）与系统性红斑狼疮（ＳＬＥ）活动度的关系。方法 ＥＬＩＳＡ法测定４６例ＳＬＥ患者及２０例正常人血浆ｓＴＭ水平，观察１９例ＳＬＥ患者治疗前后血浆ｓＴＭ变化情况。结果ＳＬＥ活动组ｓＴＭ水平高于非活动组和对照组（Ｐ＜０．０１）； ｓＴＭ与多个ＳＬＥ活动度评分相关（Ｐ＜０．００１）；治疗后ｓＪＭ水平显著降低（Ｐ＜０．０１）。结论血浆ｓＴＭ水平与ＳＬＥ活动度相关，可作为ＳＬＥ的疗效观察指标。
Objective To investigate the relationship between plasma soluble thrombomodulin (sTM) and systemic lupus erythematosus (SLE) activity. Methods The levels of sTM in 46 SLE patients and 20 healthy controls were measured by ELISA. The changes of plasma sTM in 19 SLE patients before and after treatment were observed. Results The level of sTM in SLE group was significantly higher than that in inactive group and control group (P <0.01). The sTM was correlated with multiple SLE scores (P <0.001). The level of sJM was significantly decreased after treatment (P <0. 01). Conclusion The level of plasma sTM correlates with the activity of SLE, which can be used as a measure of the efficacy of SLE.