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目的 观察葛根素治疗青光眼视神经损害的疗效。方法 对 4 7例 (6 9眼 )已行小梁切除术后14d眼压正常的有青光眼视神经损害病人随机分成两组 ,治疗组 2 6例 (38眼 ) ,用葛根素注射液治疗 ,每天 1次 ,共 4周 ,对照组 2 1例 (31眼 ) ,用能量合剂治疗 ,每天 1次 ,共 4周。观察治疗前后视力、眼压、视野、视觉诱发电位的变化。结果 3例 (4眼 )淘汰。视力提高有效率 ,治疗组 6 9 4 % ,对照组 2 0 7% (P <0 0 1) ;视野改善有效率 ,治疗组 6 3 9% ,对照组 10 3% (P <0 0 1)。结论 葛根素注射液对青光眼视神经损害有明显的增视作用。
Objective To observe the curative effect of puerarin on optic nerve damage in glaucoma. Methods Twenty-seven patients (69 eyes) undergoing trabeculectomy were randomly divided into two groups at 14 days after trabeculectomy with glaucomatous optic nerve damage. The treatment group, 26 cases (38 eyes), were treated with puerarin injection daily 1 time for 4 weeks, control group 21 patients (31 eyes), treated with energy mixture, once daily for 4 weeks. Visual acuity, intraocular pressure, visual field and visual evoked potentials were observed before and after treatment. Results 3 cases (4 eyes) were eliminated. The effective rate of visual acuity improvement was 69.4% in the treatment group and 27.0% in the control group (P <0.01). The effective rate of visual field improvement was 63.9% in the treatment group and 103% in the control group (P0.01) . Conclusion Puerarin injection can significantly increase optic nerve damage in glaucoma.