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目的 :研究活络舒肝胶囊对急性肝损伤的肝细胞保护作用。方法 :SD大鼠 30只均分为 3组 :模型组采用四氯化碳腹腔注射制作急性肝损伤模型 ;治疗组首先予以活络舒肝水溶液 6 m l/ d,分 3次灌胃 ,1周后造模 ,造模后继续给予此药灌胃 ;另设正常组比较。造模 1周后取肝组织行组织病理学检查 ,同时采集静脉血进行血浆肝酶学和血蛋白质含量的测定。结果 :模型组大鼠出现明显的肝细胞坏死 ,而治疗组大鼠坏死范围明显缩小 ,程度明显减轻 ,此外 ,电镜检查结果两组亦有差异。模型组大鼠丙氨酸氨基转移酶、门冬氨酸氨基转移酶、碱性磷酸酶值升高 ,总蛋白下降 ,与治疗组相比差异有显著性意义 (P <0 .0 5 )。结论 :活络舒肝胶囊对急性肝损伤时肝细胞具有保护作用
Objective : To study the hepatoprotective effect of Huoluo Shugan capsule on acute liver injury. METHODS: Thirty SD rats were divided into three groups: the model group was treated with intraperitoneal injection of carbon tetrachloride to make an acute hepatic injury model; the treatment group was first given a solution of active collaterals and liver 6 ml/day, three times a day, after one week Modeling, continue to give the drug gavage after modeling; set up a comparison of the normal group. One week later, hepatic tissue was taken for histopathological examination. At the same time, venous blood was collected for determination of plasma hepatic enzymology and blood protein content. Results: The rats in the model group had obvious hepatocyte necrosis, but the necrosis range of the rats in the treatment group was significantly reduced and the degree was significantly reduced. In addition, electron microscopy showed differences in the two groups. The alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels in the model group increased, and the total protein decreased. There was a significant difference compared with the treatment group (P < 0.05). Conclusion :Huoluo Shugan Capsule has protective effect on hepatocytes during acute hepatic injury