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目的:观察二黄益肾汤联合美多巴治疗帕金森病的临床疗效。方法:将134例帕金森病患者采用抽签随机化方法分为对照组与治疗组,对照组采用服用左旋多巴的复方制剂美多巴,根据病情从小剂量开始治疗,治疗组在对照组用药的基础上加服二黄益肾汤,两组均连续服药12个月为1疗程。观察临床疗效及两组治疗前后帕金森评定量表(UPDRS)评分及不良反应检测。结果:总有效率治疗组为100%,对照组为83.1%,治疗组优于对照组(P<0.05);两组治疗前后(UPDRS)评分积分自身对比均有明显改善(P<0.01),两组治疗后积分比较治疗组明显优于对照组(P<0.01);治疗组美多巴用量明显低于对照组(P<0.05);治疗组无不良反应出现。结论:二黄益肾汤联合美多巴治疗帕金森病能够明显改善临床症状、延缓病情进展、减少并发症、减小美多巴用量及副作用,使Hoehn-Yaha评级减级,且无不良反应。
Objective: To observe the clinical efficacy of Erhuang Yishen Decoction combined with Madopar in the treatment of Parkinson’s disease. Methods: A total of 134 patients with Parkinson’s disease were randomly divided into control group and treatment group by lottery randomization. The control group was treated with the compound preparation of levodopa. The control group received treatment with low dose, On the basis of serving two Huang Yishen Tang, two groups were taking 12 months for a course of treatment. To observe the clinical efficacy and the two groups before and after treatment Parkinson Rating Scale (UPDRS) score and adverse reactions. Results: The total effective rate was 100% in the treatment group and 83.1% in the control group, the treatment group was superior to the control group (P <0.05). The UPDRS scores of the two groups were significantly improved (P <0.01) The score of treatment group was significantly better than that of the control group (P <0.01). The dosage of metopar in the treatment group was significantly lower than that of the control group (P <0.05). No adverse reactions were found in the treatment group. Conclusion: Erhuang Yishen Decoction combined with Madopar in the treatment of Parkinson’s disease can significantly improve the clinical symptoms, delay the progression of the disease, reduce the complications, reduce the dose and side effects of the Madopar, grade Hoehn-Yaha without adverse reactions .