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孕妇用药对胎、婴儿的影响,近20年来才引起重视。五十年代西德市场上供应一种镇静、催眠药反应停(Thalidomide),可治早期妊娠反应,效果好,在小鼠实验中对胎仔无致畸作用,对孕妇无毒性反应,曾广泛应用于临床。但以后却发现有较多孕妇分娩出无肢或短肢、类似海豹的婴儿称海豹畸形,经多年研究发现系与孕妇在早孕时服用反应停有关,即使仅用一次、剂量在lmg/kg体重以下,也可致畸。再经孕猴实验得到证实,1961年取缔此药,此后引起人们对孕妇用药的重视。近年来药物致畸
Pregnant women medication on the fetus, the impact of infants, only attracted attention in the past 20 years. In the 1950s, a sedative and hypnotic drug Thalidomide was supplied on the West German market to treat early pregnancy reaction. It has good effect. It has no teratogenic effect on the fetus and no toxicity to pregnant women in mice. It has been widely used In clinical. But later found that more pregnant women were delivered without limbs or short limbs, similar to the seal of the baby seal abnormalities, after years of study found that pregnant women in the first trimester with taking the reaction to stop, even with only one dose at lmg / kg body weight The following can also be teratogenic. After the experiment confirmed by pregnant monkeys, banned this medicine in 1961, and then caused people to pay attention to the medication of pregnant women. In recent years, drug teratogenicity