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我院两年来发生二例奎尼丁晕厥报道于下:例1:男性,56岁,干部。患冠心病心绞痛气短半年,心房纤颤二个月。血压150/90,心脏中等度增大,心功Ⅲ级。1982年7月12日予奎尼丁片0.2,日5次;心得安片20毫克 tid。次日奎尼丁加至0.3日5次,加苯妥英钠片0.1tid;下午4时总量达2.5克,心电图恢复窦性心律,但 QTc 从0.40秒延长至0.52秒;服末次药4.5小时后,于卧床中突然抽搐紫绀,不省人事,呼吸停止,心音消失。抢救1分钟后抽搐停止,意识转清醒。
Two cases occurred in our hospital Quinidine syncope in the next two reports: Example 1: Male, 56 years old, cadres. Coronary heart disease Angina pectoris short half a year, atrial fibrillation two months. Blood pressure 150/90, moderate increase in heart, heart work grade III. July 12, 1982 to quinidine 0.2, day 5 times; experience An tablets 20 mg tid. The next day, quinidine was added to 0.3 times on the 3rd, 0.1 hour with phenytoin sodium, and 2.5 grams at 4:00 PM. The electrocardiogram recovered sinus rhythm but the QTc was extended from 0.40 seconds to 0.52 seconds. 4.5 hours after the last dose , Suddenly twitching cyanosis in bed, unconscious, breathing stopped, heart sound disappeared. Rescue 1 minute after the convulsions stopped, consciousness turn to awake.