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目的:探究与分析子宫内膜异位症与血清、腹腔液中CA125、TNF-α的相关性。方法:本次研究选取2015-06-2016-06收治的子宫内膜异位症患者60例为观察组,另选取同期健康体检女性60例为对照组,同时将观察组患者按照不同时期分为Ⅰ期14例,Ⅱ期14例,Ⅲ期17例,Ⅳ期15例,观察与分析血清及腹腔镜液中CA125、TNF-α水平与子宫内膜异位症发生、发展的关系。结果:观察组血清CA125、TNF-α水平及腹腔液中CA125、TNF-α水平较对照组高,差异有统计学意义(P<0.05)。Ⅲ期与Ⅳ期组与Ⅰ期与Ⅱ期组相比血清CA125、TNF-α水平及腹腔液中CA125、TNF-α水平均较高,差异有统计学意义(P<0.05)。结论:子宫内膜异位症血清与腹腔液中CA125、TNF-α水平要明显高于健康妇女,二者的水平与疾病发生、发展具有密切关系,有利于临床工作中对子宫内膜异位症的诊断。
Objective: To explore and analyze the correlation between endometriosis and serum and peritoneal fluid CA125, TNF-α. Methods: In this study, 60 patients with endometriosis admitted from June 2015 to June 2016 were selected as the observation group. Another 60 healthy women in the same period were selected as the control group. At the same time, the patients in the observation group were divided according to different periods 14 cases of stage Ⅰ, 14 cases of stage Ⅱ, 17 cases of stage Ⅲ and 15 cases of stage Ⅳ. The relationship between CA125 and TNF-α in serum and laparoscopic fluid and the occurrence and development of endometriosis was observed and analyzed. Results: The levels of serum CA125 and TNF-α in the observation group and the levels of CA125 and TNF-α in the peritoneal fluid were significantly higher than those in the control group (P <0.05). The levels of serum CA125 and TNF-α and the levels of CA125 and TNF-α in peritoneal fluid in stage Ⅲ and Ⅳ were significantly higher than those in stage Ⅰ and Ⅱ (P <0.05). Conclusion: The levels of CA125 and TNF-α in serum and peritoneal fluid of patients with endometriosis are significantly higher than those of healthy women. The level of CA125 and TNF-α in endometriosis is closely related to the occurrence and development of disease, which is beneficial to the treatment of endometriosis Diagnosis of disease.