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Due to interesting therapeutic properties of ~(153)Sm and antineoplastic antibiotic,bleomycin(BLM), ~(153)Sm-bleomycin(~(153)Sm-BLM) was developed as a possible therapeutic compound using ~(153)SmCl_3 and BLM.The ~(153)SmCl_3 was obtained by thermal neutron flux(5×10~(13)n·cm~(-2)·s~(-1))of an enriched ~(152)Sm_2O_3 sample,dissolved in acidic media.Under optimized conditions(room temperature,45 min,0.1 mg bleomycin for 740-3700 MBq ~(153)SmCl_3) a radiochemical purity over 98%was obtained shown by HPLC(Specific activity = 55 TBq/mM).The ~(153)SmCl_3 and ~(153)Sm-BLM were administered into wild-type rats up to 96 h followed by biodistribution.The SPECT imaging of labeled compound in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin compound.The ~(153)Sm-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality,and stability suitable for future therapeutic studies.
Due to interesting therapeutic properties of ~ (153) Sm and antineoplastic antibiotic, bleomycin (BLM), ~ (153) Sm-bleomycin BLM.The ~ (153) SmCl_3 was obtained by thermal neutron flux (5 × 10 ~ (13) n · cm ~ (-2) · s -1) of an enriched ~ (152) Sm_2O_3 sample, dissolved in acidic media. Un optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 740-3700 MBq ~ (153) SmCl_3) a radiochemical purity over 98% was obtained by HPLC (Specific activity = 55 TBq / (153) SmCl_3 and ~ (153) Sm-BLM were administered into wild-type rats up to 96 h followed by biodistribution.The SPECT imaging of labeled compounds in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin compound. ~ (153) Sm-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality, and stability suitable for future therapeutic studies.