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目的:研究葛根素对急性脑缺血再灌注损伤所致神经细胞损害的保护作用。方法:完全阻断大脑中动脉致其所支配的特定区域缺血缺氧30min,然后再恢复血流30min,制作大鼠急性脑缺血再灌注损伤模型;药物组预先给予葛根素注射液,对照组给予等剂量的生理盐水;观察和比较两组脑神经细胞损伤的病理形态学变化,计算其脑神经细胞的死亡率和葛根素干预后的保护关联强度。结果:葛根素干预组的脑神经细胞损伤程度明显轻于生理盐水对照组,葛根素干预与脑神经细胞死亡呈显著负相关。结论:葛根素对急性脑缺血再灌注损伤所致的脑神经细胞损害具有一定的保护作用。
Objective: To study the protective effect of puerarin on neuronal damage induced by acute cerebral ischemia-reperfusion injury. METHODS: The cerebral ischemia and hypoxia induced by the middle cerebral artery was completely blocked for 30 min, and then the blood flow was resumed for 30 min. The rat model of acute cerebral ischemia-reperfusion injury was made. The drug group was given puerarin injection in advance. The rats were given equal doses of physiological saline. The pathological changes of the nerve cell injury in the two groups were observed and compared. The death rate of cerebral nerve cells and the protection related intensity after puerarin intervention were calculated. RESULTS: The damage degree of cerebral nerve cells in the puerarin-treated group was significantly lower than that in the normal saline control group. There was a significant negative correlation between puerarin and brain cell death. Conclusion: Puerarin has a certain protective effect on cerebral neuronal damage induced by acute cerebral ischemia-reperfusion injury.