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对结直肠癌肝转移来说,手术是惟一的治愈手段。但80%的病人初始是不可切除的,将不可切除肝转移转化为可切除是提高结直肠癌总体存活率的关键。目前常用的转化手段有全身化疗(包括单纯化疗、化疗联合靶向药物等)、肝动脉灌注(HAI)、射频消融(RFA)、联合门静脉结扎或栓塞的分期肝切除、联合肝脏分隔及门静脉结扎的二步肝切除等。了解各种转化治疗的有效率和适应证是选择合适治疗的前提。
For colorectal liver metastases, surgery is the only cure. However, 80% of patients are initially unresectable and the conversion of unresectable liver metastases to resectability is the key to improving overall survival in colorectal cancer. Commonly used transformation methods include systemic chemotherapy (including chemotherapy alone and chemotherapy combined with targeted drugs), hepatic arterial perfusion (HAI), radiofrequency ablation (RFA), staged hepatectomy combined with portal vein ligation or embolization, combined with hepatic compartmentalization and portal vein ligation Two-step liver resection and so on. Understanding the effectiveness and indications of various conversion therapies is a prerequisite for choosing the right treatment.