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肾上腺皮质激素如用量较大,疗程较长,会产生诸如感染的感受性增加、垂体-肾上腺皮质机能受抑制以及多种代谢紊乱等副作用,在很大程度上限制了它的应用。为了克服这些副作用,采用了以下一些方法:①合成新的类固醇,企图由化学结构的改变导致生理-药理作用的分离,但是,到目前为止,只解决了对电解质的副作用,如强的松的潴钠排钾作用较氢化可的松为轻,地塞米松基本上无潴钠作用;
Adrenocorticotropic hormone, such as a larger amount, a longer course of treatment, will have such as increased susceptibility to infection, pituitary - adrenal cortex function inhibition and a variety of metabolic disorders and other side effects, to a large extent limit its application. In order to overcome these side effects, the following methods have been used: ① The synthesis of new steroids in an attempt to separate the physiologic-pharmacological effects caused by the change of the chemical structure, but so far only the side effects on the electrolytes, such as prednisone Sodium retention potassium row hydrocortisone lighter than hydrocortisone, dexamethasone basically no retention of sodium;