血友病A是一种性联隐性遗传性出血性疾病,特点是罹病者缺乏因子Ⅷ凝血活性。此病由杂合子女性传递,半合子男性患病;纯合子女性患者极少见。由于本病患者终身罹病,对社会及家庭都有很大影响,而女性传递者在临床上一般正常,因此检测传递者有着重要的实际意义。目前,在经济发达国家已应用于遗传咨询。在遗传学及家谱资料的基础上,可以把与血友病人有亲属关系的女性分为二类:1.肯定传递者,包括血友病人的女儿,有一个以上血友病儿子的妇女和有一个血友病儿子及一个 Hemophilia A is a sexually associated hereditary hemorrhagic disease characterized by a lack of factor Ⅷ coagulation activity in patients with disease. The disease is transmitted by heterozygous women, hemizygous men sick; homozygous female patients rare. Because of the patient’s lifelong illnesses, have a great impact on society and family, and the female transferer is generally normal in the clinic, so the test delivery has an important practical significance. At present, it has been applied to genetic counseling in economically developed countries. On the basis of genetic and pedigree data, women with kinship with haemophilia can be classified into two categories: 1. Definitely passed on, including daughters of hemophilia, women with more than one hemophilia son and A hemophilia son and one