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目的探讨非甾体抗炎药物(NSAIDs)致上消化道出血的临床特点。方法统计消化内科上消化道出血住院患者169例的临床资料,根据出血前1周内是否服用NSAIDs,将其分为两组进行比较。结果非甾体抗炎药物(NSAIDs)致上消化道出血有53例(31.36%),两组患者性别、消化道溃疡史、出血程度比较,差异无统计学意义(P>0.05),但NSAIDs组年龄偏大,出血前消化道症状不明显,胃镜下见弥散性黏膜充血、水肿及多发性糜烂表浅溃疡者更易发生出血(P<0.05)。结论NSAIDs是上消化道出血的重要病因,应采取适宜措施预防不良反应的发生。
Objective To investigate the clinical features of non-steroidal anti-inflammatory drugs (NSAIDs) induced upper gastrointestinal bleeding. Methods The clinical data of 169 cases of inpatients with gastrointestinal bleeding in gastroenterology were collected and divided into two groups according to whether they took NSAIDs within 1 week before the bleeding. Results There were 53 cases (31.36%) of upper gastrointestinal hemorrhage caused by NSAIDs. There was no significant difference in gender, history of peptic ulcer and bleeding between the two groups (P> 0.05). However, NSAIDs Group age is too large, gastrointestinal symptoms before bleeding is not obvious, see diffuse mucosal congestion under endoscopy, edema and multiple erosion of superficial ulcers were more prone to bleeding (P <0.05). Conclusion NSAIDs is an important cause of upper gastrointestinal bleeding. Appropriate measures should be taken to prevent the occurrence of adverse reactions.