OBJECTIVE To evaluate the effect of aqueousstem extract of Tinsporacordifolia(TCSE)on 1.experimentally induced diabetic peripheral neuropathy(DPN)2.Serum triglycerides(TG),high density lipoproteins(HDL)and atherogenic index(AI)in type 2 diabetic patients.METHODS Experimental study:TCSE was evaluated on streptozotocin induced diabetic Wistar albino rats on the reaction time(RT)to radiant heat in tail flick test.The diabetic animals were grouped into diabetic control group(DC),standard control group(SC)that received glibenclamide+metformin;TCSE 1,TCSE2,and TCSE 3 that received 100,200 and 400mg·kg-1 of TCSE respectively.Another group served as the normal control group(NC).The medications were administered once daily orally for 2 weeks after the induction of diabetes.RT was compared among these groups.Clinical study:20 Type 2 diabetes mellitus patients with TG >200mg·dL-1 and HDL<50mg·dL-1 were randomised to receive either Rosuvastatin 10 mg or TCSE 300 mg per day once daily for 12weeks.After 12 weeks,TG,HDL and AI(calculated as the log 10 of the ratio of TG with HDL)were analysed within the group and compared between the groups.Mann Whitney U test was applied for analysis for both.RESULTS Experimental study:RT was 10.0±0.7sin the NC,7.83±1.19 sin DC(P<0.05 compared to NC)indicating hyperalgesia.SC,TC1,TC2,and TC3 showed 12.83±0.31,13.33±0.88;13.67±1.09and15.25±0.23 s,respectively(P<0.05 compared to DC).Clinical study:In the clinical study,in theTCSE group,TG reduced from 251.62±15.22 to 212.2±11.83 mg·dL-1;HDL increased from 34.53±0.74to40.81±0.71mg·dL-1 and mean AI reduced from 0.83±0.028 to 0.70±0.027.In the rosuvastatin group TG levels decreased from 255.8±13.03 to 196.3±12.84 mg·dL-1;HDL increased from 37.38±0.77to43.3±1.21mg·dL-1 and mean AI reduced from 0.83±0.02 to 0.65±0.03.The change was statistically significant within each groups but not between the groups.CONCLUSION The aqueous extract of Tinosporacordifolia appears to be effective in reducing the diabetic peripheral neuropathy and atherogenic index. OBJECTIVE To evaluate the effect of aqueousstem extract of Tinspora cordifolia (TCSE) on 1. experimentally established diabetic peripheral neuropathy (DPN) 2.Serum triglycerides (TG), high density lipoproteins (HDL) and atherogenic index (AI) METHODS Experimental study: TCSE was evaluated on streptozotocin induced diabetic Wistar albino rats on the reaction time (RT) to radiant heat in tail flick test. The diabetic animals grouped into diabetic control group (DC), standard control group (SC) that received TCSE 1, TCSE 2, and TCSE 3 that received 100, 200 and 400 mg · kg -1 of TCSE respectively. Another group served as the normal control group (NC). The medications were administered once daily orally for 2 weeks after the induction of diabetes. RT was compared among these groups. Clinical study: 20 Type 2 diabetes mellitus patients with TG> 200 mg · dL-1 and HDL <50 mg · dL-1 were randomized to receive either Rosuvastatin 10 mg or TCSE 300 mg per day once daily for 12week s. After 12 weeks, TG, HDL and AI (calculated as the log 10 of the ratio of TG with HDL) were analyzed within the group and compared between the groups. Mann Whitney U test was applied for analysis for both. (P <0.05 compared to NC) indicating hyperalgesia. SC, TC1, TC2, and TC3 showed 12.83 ± 0.31, 13.33 ± 0.88; 13.67 ± 1.09 and 15.25 ± 0.23 s, respectively (P <0.05 compared to DC). Clinical study: In the clinical study, in the TCSE group, TG reduced from 251.62 ± 15.22 to 212.2 ± 11.83 mg · dL-1; HDL increased from 34.53 ± 0.74 to 40.81 ± 0.71 mg · dL-1 and mean AI reduced from 0.83 ± 0.028 to 0.70 ± 0.027. TG levels of the rosuvastatin group decreased from 255.8 ± 13.03 to 196.3 ± 12.84 mg · dL-1; HDL increased from 37.38 ± 0.77 to 43.3 ± 1.21 mg · dL-1 and mean AI reduced from 0.83 ± 0.02 to 0.65 ± 0.03. The change was significant within each groups but not between the groups. CONCLUSION The aqueous extract of Tinospora cordifolia appeared to be effective in reducing the diabeticperipheral neuropathy and atherogenic index.