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对Ｗｉｓｔｅａｒ大鼠做缺锌饲养并以Ｎ－甲基－Ｎ′硝基－Ｎ亚硝基胍（ＭＮＮＧ）作为致癌剂，观察缺锌对大鼠胃癌发生率的影响。结果显示，缺锌组动物１００％呈现前胃粘膜中度或高度增生；而对照组上皮增生发生率仅５２．５％，中、重度增生者为１５％；两组动物胃粘膜增生的严重程度及发生频率有显著差别。实验组２例大鼠胃腺区发生非典型增生，对照组无此种现象。结果还显示，缺锌大鼠发生前胃癌的危险性增加。两组差异显著（Ｐ＜０．０１）。提示适量锌具有保护胃粘膜，抑制肿瘤发生的作用；缺锌是导致胃癌发生率升高的危险因素。
Wistear rats were bred in zinc-deficient and N-methyl-N ’nitro-N-nitrosoguanidine (MNNG) was used as a carcinogen to observe the effect of zinc deficiency on the incidence of gastric cancer in rats. The results showed that 100% of the zinc-deficient animals showed moderate or hyperproliferation of the anterior gastric mucosa, whereas the incidence of epithelial hyperplasia was only 52.5% in the control group and 15% in the moderate and severe hyperplasia rats. The severity of gastric mucosal hyperplasia And the frequency of occurrence of significant differences. In the experimental group, 2 cases of gastric adenosis in atypical hyperplasia, the control group without this phenomenon. The results also showed that zinc deficiency in rats before the increased risk of gastric cancer. There was significant difference between the two groups (P <0.01). Prompted the appropriate amount of zinc has the function of protecting the gastric mucosa and inhibiting tumorigenesis; zinc deficiency is a risk factor leading to the increased incidence of gastric cancer.