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目的:了解布吡卡因碱化溶液的药效。方法:①离体坐骨神经法:取蟾蜍60 只,制备坐骨神经标本,分两组,实验组( 碱化布吡卡因组) 和对照组( 盐酸布吡卡因组) 各30 只,测定不同浓度的两组布吡卡因对离体坐骨神经动作电位(AP) 幅度的影响;②在体坐骨神经丛法:取蟾蜍60 只,分组同上,破坏第三脊椎以上的脊髓后,将不同浓度的两种布吡卡因注入蟾蜍的腹腔内,测定其缩腿反射消失的时间。结果:实验一显示,实验组与对照组ED50 之比为1∶2 .7 ;实验二显示,实验组缩腿反射消失的时间明显短于对照组( P< 0 .01) 。结论:碱化布吡卡因对传导麻醉的作用强度显著大于盐酸布吡卡因,且对蟾蜍坐骨神经阻滞的速度明显加快
Objective: To understand the efficacy of Bupivacaine alkalizing solution. Methods: ① In vitro sciatic nerve method: Sixty toads were prepared and sciatic nerve specimens were prepared and divided into two groups. The experimental group (30 mg / kg) and the control group (Bupivacaine hydrochloride group) Of the two groups of bupivacaine on isolated rat sciatic nerve action potential (AP) amplitude; ② in sciatic nerve plexus method: take toad 60, the same group as above, destroy the third spinal cord above the spinal cord, the different concentrations of two Bupivacaine into the peritoneal cavity of toads to measure the disappearance of reflex contraction time. Results: Experiment 1 showed that the ratio of ED50 in experimental group and control group was 1: 2. Experiment 2 showed that the disappearance of reflex in experimental group was significantly shorter than that in control group (P <0.01). CONCLUSION: Bupivacaine alkaloids have a greater effect on conduction anesthesia than bupivacaine hydrochloride and significantly accelerate the sciatic nerve block in toads