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为了观察SARS患者血清Ⅳ型胶原含量变化 ,本文用RIA检测了 6 6例SARS患者血清Ⅳ型胶原含量 ,并与对照组比较。结果表明 :恢复期的SARS患者Ⅳ型胶原含量明显高于对照组 ,恢复期患者血清Ⅳ型胶原含量高于正常值的百分率为 2 8.7% (19/6 6 )。X线胸片病灶吸收缓慢的SARS患者Ⅳ型胶原含量较高。本文提示SARS患者Ⅳ型胶原含量增高 ,与肺部病灶吸收和纤维化程度有关。因此动态观察血清Ⅳ型胶原含量 ,可能是监测肺纤维化的较好指标之一。
In order to observe the change of serum type Ⅳ collagen in patients with SARS, the serum level of type Ⅳ collagen in 66 cases of SARS was detected by RIA and compared with the control group. The results showed that the content of type Ⅳ collagen in convalescent SARS patients was significantly higher than that in the control group, and the percentage of serum type Ⅳ collagen in patients with convalescent convalescence was 28.7% (19/6 6). Type X collagen is high in SARS patients with slowly absorbed X-ray lesions. This article suggests that patients with SARS increased collagen type Ⅳ, and lung lesions and fibrosis related to the degree of absorption. Therefore, dynamic observation of serum type Ⅳ collagen content may be one of the better indicators to monitor pulmonary fibrosis.