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目的 分析采用卵胞浆内单精子注射 (ICSI)和常规体外受精 (IVF)联合治疗畸形精子症的疗效。方法 对 72例精液分析轻度异常的患者采用常规IVF和ICSI联合治疗方案 ,根椐精子形态分为精子形态正常组和畸形精子症组。结果 精子形态正常组共 3 9例 ,其ICSI的受精率、卵裂率、优质胚胎率分别为 71 7%,86 7%,43 4%;常规IVF分别为 68 2 %,89 0 %,47 0 %。精子正常形态组的ICSI与常规IVF的受精率、卵裂率、优质胚胎率无明显差异 (P >0 0 5 )。畸形精子症组为 3 3例 ,其ICSI的受精率、卵裂率、优质胚胎率分别为 73 9%,92 5 %,5 6 9%;常规IVF分别为5 3 2 %,86 8%,3 9 2 %。畸形精子症组的ICSI的受精率、优质胚胎率高于常规IVF(P <0 0 1,P <0 0 5 )。结论 ICSI与常规IVF联合治疗畸形精子症 ,可保证较高的受精率 ,避免全部受精失败现象。采用ICSI方法治疗畸形精子症优于常规IVF。
Objective To analyze the therapeutic effect of combined intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF) on deformity sperm disease. Methods A total of 72 patients with mild abnormal semen analysis underwent routine IVF and ICSI regimen. The morphology of sperm was divided into normal spermatozoa group and abnormal sperm group. Results There were 39 cases with normal sperm morphology. The rates of fertilization, cleavage and high quality embryos of ICSI were 71.7%, 86.7% and 43.4%, respectively. Conventional IVF were 68.2%, 89.0%, 47 0%. There was no significant difference in fertilization rate, cleavage rate and high quality embryos between normal sperm morphology group and conventional IVF group (P> 0.05). The deformity sperm group was 33 cases. The ICSI fertilization rate, cleavage rate and high-quality embryo rate were 73 9%, 92 5% and 59 6%, respectively. Conventional IVF was 53 32% and 86 8% respectively, 3 9 2%. The rates of fertilization and high-quality embryos in ICSI with malformed spermatozoa were higher than those with normal IVF (P <0.01, P <0.05). Conclusion ICSI and conventional IVF combined treatment of deformity sperm disease, to ensure a higher fertilization rate, to avoid the phenomenon of all fertilization failure. ICSI treatment of abnormal sperm disease is superior to conventional IVF.