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自从1960年Shepard报告小白鼠足垫繁殖麻风杆菌成功以来,麻风病化疗研究有了很大的进展,鼠足垫繁殖麻风杆菌这一实验工具为鉴定药物疗效和筛选新的抗麻风药物提供了可靠的方法。与此同时,砜类药物的药理学研究亦有一定的进展,因而目前已有可能把麻风病的化疗建立在客观的细菌学和药理学的基础上,从而使麻风病的治疗水平大大前进一步。现就几个方面的问题简单综述如下:
Since the 1960 Shepard report on the successful maturation of leprosy in footpads of mice, there has been considerable progress in the leprosy chemotherapy and the experimental tools for the development of leprosy in rat foot pads have provided reliable evidence of drug efficacy and selection of new anti-leprosy drugs Methods. At the same time, pharmacological studies on sulfone drugs have also made some progress, so that it is now possible to base the leprosy chemotherapy on objective bacteriology and pharmacology so that the level of treatment for leprosy can be greatly advanced . A few simple questions are summarized as follows: