临床上关于抗酸药对胃溃疡疗效的研究并不多,且大多数的研究均不满意。因此,作者在胃溃疡住院患者中,用抗酸药和安慰剂治疗,比较他们对胃溃疡的止痛及促进溃疡愈合方面的作用。经纤维胃镜确诊为胃溃疡的28例患者,随机分配15例服抗酸药,13例服安慰剂。所有患者住院3周治疗观察。每例最初均作胃镜检查,并作活检,同时测定溃疡面最宽的2个直径。每周询问患者有关胃痛、腹泻、呕吐和其它胃肠症状1次。在第3周末,再作胃镜复查。若溃疡未完全愈合者,每两周重检1次,直至溃疡愈合或用手术治疗为止。抗酸药组服抗酸药合剂,每5毫升含有氢氧化铝200毫克,氢氧化镁200毫克,Simethicone 20毫克。安慰剂为含有乳糖、单糖等的合剂。在非睡眠期间每2小时服约30毫升。在观察期间,不限制饮食,不戒烟。在3周内,安慰剂组13例患者中,8例溃疡愈合,另2例溃疡面缩小了2/3,最后在门诊治疗完全愈合,还有3例未愈合者作手术治疗。抗酸药组15例患者中,8例溃疡完全愈合,另3例溃疡面缩小了 Clinically, there are not many studies on the antacid effect on gastric ulcer, and most of the studies are not satisfied. Therefore, the authors were treated with antacids and placebo in hospitalized patients with gastric ulcer to compare their analgesic effects on gastric ulcer and promote healing of ulcer. Twenty-eight patients diagnosed with gastric ulcer by fibroid gastroscopy were randomized to receive antacid 15 and placebo 13. All patients were hospitalized for 3 weeks treatment observation. Each case was initially endoscopy and biopsy, while measuring the widest two ulcers surface diameter. Patients are asked weekly about stomach pain, diarrhea, vomiting and other gastrointestinal symptoms 1 time. In the third weekend, and then for endoscopy. If the ulcer is not completely healed, re-test once every two weeks, until the ulcer healed or surgically treated. Antacids group antacid mixture, containing 200 mg of aluminum hydroxide per 5 ml, 200 mg of magnesium hydroxide, Simethicone 20 mg. Placebo is a mixture containing lactose, monosaccharides and the like. About 30 ml every 2 hours during non-sleep. During the observation period, do not limit the diet, do not quit smoking. Of the 13 patients in the placebo group who had healed in 8 of 3 patients in the placebo group and 2/3 of the other 2 in the placebo group, they were completely healed in the outpatient setting and 3 of the non-healed patients were surgically treated. Of 15 patients in the antacid group, 8 had ulceration completely and 3 had ulceration