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1963～1968年设计的三种对照试验证明,慢性活动性肝炎用类固醇或类固醇与硫唑嘌呤联合治疗有效,单用硫唑嘌呤无效。这种既往预后不良的疾病,用此治疗70％可有2年缓解率。虽然,重症 HBsAg阳性的慢性活动性肝炎患者,对常规皮质类固醇的治疗反应往往比 HBsAg 阴性者差;但 HBsAg 阳性并不妨碍其对类固醇治疗的良好反应。HBsAg 阳性患者用强的松治疗的效果,主要取决于治疗前的临床状况,年老和昏迷是治疗反应不好的因素,大多数病人用常规或大剂量类固醇治疗后,有生化和症状的改善。
Three controlled trials designed from 1963 to 1968 demonstrated that chronic active hepatitis was efficacious with steroids or steroids in combination with azathioprine and azathioprine alone. This past poor prognosis of the disease, with 70% of this treatment can have 2-year response rate. Although patients with severe active HBsAg-positive chronic active hepatitis have a worse response to conventional corticosteroids than HBsAg-negative patients, positive HBsAg does not prevent their good response to steroid therapy. The efficacy of prednisone in HBsAg-positive patients depends primarily on the pre-treatment clinical condition, age, and coma that are responsible for the poor response to treatment, and most patients have biochemical and symptomatic improvement after treatment with either conventional or high-dose steroids .