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本文主要介绍促性腺激素释放激素(Gn-RH).黄体生成素(LH)、卵泡刺激素(FSH)和催乳激素(PRL)等的神经内分泌调节机理。 1、下丘脑—垂体的解剖 人类下丘脑能生成Gn-RH。可分为室旁部、内侧部和外侧部3部分。用免疫组织化学法发现人和灵长类的Gn-RH在内侧基底丘脑下部(MBH)的弓状核和前乳头核,神经纤维伸向正中隆起外侧部。该部位能检出直径约80nM的Gn-RH分泌颗粒,经垂体门脉系统进入垂体前叶。 下丘脑功能除受卵巢分泌的雌激素和孕激素的长反馈外,还受垂体分泌的LH,FSH等经门脉返流的短反馈而抑制分泌。此外,Gn-RH能“自我”
This article describes the neuroendocrine regulatory mechanisms of gonadotropin-releasing hormone (Gn-RH), luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin (PRL). 1, hypothalamus - anatomy of the pituitary human hypothalamus can generate Gn-RH. It can be divided into 3 compartments, anterior and lateral. Human and primate Gn-RH were found in the arcuate nucleus of the medial basal hypothalamus (MBH) and the anterior papilla nucleus by immunohistochemistry. The nerve fibers projected to the lateral side of the median bulge. This site can detect Gn-RH secretory granules with a diameter of about 80 nM and enter the anterior pituitary through the pituitary portal system. In addition to the long-term feedback of estrogen and progesterone secreted by the ovary, hypothalamic function is also inhibited by short feedback of portal regurgitation such as LH, FSH secreted by the pituitary gland. In addition, Gn-RH can “self”