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目的研究口服核苷酸对实验性高脂血症大鼠血脂水平的影响。方法选用60只健康雄性SD大鼠分成正常对照、高脂模型对照和0.04,0.16,0.64g/kg体重核苷酸组,正常对照组大鼠饲喂普通饲料,高脂模型和核苷酸组大鼠饲喂高脂饲料。核苷酸组大鼠以灌胃方式给予不同剂量的核苷酸(1ml/100g)45d,测定血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇含量。结果摄入核苷酸45d后,0.04,0.16,0.64g/kg体重组大鼠血清总胆固醇(TC)分别为(3.14±1.45),(3.65±1.58),(3.14±1.70)mmol/L,0.04g/kg体重组及0.64g/kg体重组与高脂模型对照组(4.26±1.96)mmol/L相比显著降低;甘油三酯(TG)含量分别为(0.93±0.53),(0.93±0.44),(0.72±0.38)mmol/L,0.64g/kg体重组与高脂模型对照组〔(1.29±0.49)mmol/L〕相比显著降低;高密度脂蛋白胆固醇(HDL-C)分别为(1.19±0.31),(1.22±0.31),(1.26±0.36)mmol/L,与高脂模型对照组〔(1.09±0.16)mmol/L〕相比差异无统计学意义。结论口服核苷酸具有一定的辅助降血脂功能,并提示其对动脉粥样硬化的发生具有一定的预防作用。
Objective To study the effects of oral nucleotides on blood lipids in experimental hyperlipidemic rats. Methods Sixty healthy male Sprague-Dawley rats were divided into normal control group, high fat model control group and 0.04,0.16,0.64g / kg body weight nucleotide group. The rats in normal control group were fed with normal diet, high fat model and nucleotide group Rats fed high-fat diet. Nucleotide group rats were administered with different dosages of nucleotides (1ml / 100g) for 45 days by gavage, and serum total cholesterol, triglyceride and high density lipoprotein cholesterol levels were measured. Results Serum total cholesterol (TC) in the 0.04, 0.16 and 0.64 g / kg body weight groups were (3.14 ± 1.45), (3.65 ± 1.58) and (3.14 ± 1.70) mmol / L, 0.04g / kg body weight group and 0.64g / kg body weight group were significantly lower than that of the high-fat model control group (4.26 ± 1.96) mmol / L; the content of triglyceride were (0.93 ± 0.53) and 0.44), (0.72 ± 0.38) mmol / L and 0.64 g / kg body weight respectively. Compared with the high fat model control group (1.29 ± 0.49 mmol / L〕, the levels of HDL-C (1.19 ± 0.31), (1.22 ± 0.31) and (1.26 ± 0.36) mmol / L, respectively. There was no significant difference between the two groups ([1.09 ± 0.16] mmol / L] Conclusion Oral nucleotides have some hypolipidemic effect, and suggest that it has a preventive effect on the occurrence of atherosclerosis.