心脏再生治疗有望改变现有的心血管病治疗局面,直接重编程领域的研究为实现这一目标提供了新的有力工具。直接重编程是近年来广泛应用于细胞修复及器官移植研究的一项技术,可绕过诱导多功能干细胞中间阶段,直接将一种终末分化细胞转化为其他种类的终末分化细胞。总结了直接重编程用于心脏再生治疗的研究进展,探讨直接重编程技术尚存的问题和障碍,并展望其未来在再生医学领域的应用。 Cardiac regenerative therapy is expected to change the existing treatment of cardiovascular disease, research in the field of direct reprogramming has provided a new powerful tool to achieve this goal. Direct reprogramming is a technique widely used in the research of cell repair and organ transplantation in recent years. It can bypass the intermediate stage of induction of pluripotent stem cells and transform one kind of terminally differentiated cells directly into other kinds of terminally differentiated cells. The research progresses of direct reprogramming for cardiac regenerative therapy are summarized, and the remaining problems and obstacles of direct reprogramming technology are explored, and their future applications in the field of regenerative medicine are prospected.