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目的探讨15例变应性肉芽肿性血管炎(CSS)患者的临床表现及病理特点,提高对该病的认识。方法回顾性分析总结15例CSS患者的临床表现及实验室资料。结果15例中有7例分别以多发性单神经炎(3/7)、胃肠道病变(2/7)及皮肤病变(2/7)为首发症状。全部病例周围血嗜酸细胞增高,活检显示CSS的3种典型的病理改变通常出现在疾病的不同阶段。结论CSS单次活检可能看不到病变全貌,必要时需进行多次活检。
Objective To investigate the clinical features and pathological features of 15 patients with allergic granulomatous vasculitis (CSS) and to improve their understanding of the disease. Methods The clinical manifestations and laboratory data of 15 cases of CSS patients were retrospectively analyzed and summarized. Results Among the 15 cases, 7 cases had multiple mononeuritis (3/7), gastrointestinal lesion (2/7) and skin lesion (2/7) as the first symptom. All cases of peripheral blood eosinophilia, biopsy showed that three typical CSS pathological changes usually occur in different stages of the disease. Conclusion CSS single biopsy may not see the entire picture of the lesion, if necessary, multiple biopsies.